The latest publication of the new LCQB team “Telomere and Genome Stability” (Héloïse Coutelier and Zhou Xu) makes the cover of the December issue of Genes & Development! The article (Coutelier et al. 2018 Genes Dev.) shows that telomere-induced senescent cells can adapt to the DNA damage checkpoint safeguard mechanism to force cell division, leading to increased genome instability, with important ramifications for aging and cancer. The cover displays cells bearing a fluorescent reporter construct monitoring of the checkpoint status in single cells.
Telomere and Genome Stability
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