Responses to fluctuating environmental conditions are based on sophisticated signaling and metabolic regulation networks where reactive oxygen, nitrogen and sulfur species play a key role.
They act mainly on specific protein cysteines by a set of redox post-translational modifications (disulfide bridges, nitrosylation, glutathionylation, persulfidation…).
These modifications are controlled by the small oxidoreductases thioredoxins and glutaredoxins. We are developing, mainly in Chlamydomonas reinhardtii, innovative approaches combining chemobiology, synthetic biology and systems biology to 1/ understand the dynamics and plasticity of these redox modification networks and 2/ understand at the molecular level how reactive species, redox modifications and redox proteins act together to rapidly modulate cellular processes and metabolic pathways in order to allow adaptation and survival.
