OUTREACHS

The CST complex, a new player in DNA repair

Take a look at this CNRS outreach article about our recent publication:

https://www.insb.cnrs.fr/fr/cnrsinfo/le-complexe-cst-un-acteur-inattendu-de-la-reparation-de-ladn

 

For more information: Ilioaia O, Dudragne L, Brocas C, Meneu L, Koszul R, Dubrana K, Xu Z. The CST complex mediates a post-resection non-homologous end joining repair pathway and promotes local deletions in Saccharomyces cerevisiae. Cell Genom. 2025 Jul 8:100947. doi: 10.1016/j.xgen.2025.100947. Epub ahead of print. PMID: 40675158.

Teams: Telomere & Genome Stability

Biolit Mission

The HEAL group was pleased to participate in the Biolit mission https://biolit.fr/ for the International Day of Global Biodiversity on May 24, 2025.

BioLit is a participatory science program on coastal biodiversity, created and supported by Planète Mer. It is run under the scientific responsibility of the Dinard marine station of the Museum National d’Histoire Naturelle (MNHN). It enables everyone to take action to better understand and preserve the biodiversity of the seaside.

We spent a day counting algal and mollusc species at the épave de l’OTAN at Octeville, Normandie, France. The best part of the day was apparently the beer at the end 🙂

Teams: Horizontal Evolution of Algal Lifestyles (HEAL)

LeDNA mission

The HEAL group was pleased to participate in the LeDNA mission, organized for the International Day of Global Biodiversity on May 22, 2024 https://environmental-dna.ethz.ch/research/ercledna/global-lake-sampling.html.

The global loss and redistribution of biodiversity is a hallmark of the Anthropocene. Our challenge is to generate information about how altered biodiversity influences ecosystems and use this information to change our impact on the biosphere. To meet this challenge, we must know where species are, how their distributions change in time and why. However, current methods for determining species distributions are expensive, time intensive and hard to do for multiple species and large geographic regions-​ rendering global trend analysis near infeasible. We therefore need a paradigm shift. In this project we utilize the biotechnology of the fourth industrial revolution (i.e., inexpensive sequencing and computational power) to empirically change how we sample animal and plant biodiversity to solve the infeasibility problem of tracking multiple species distributions on large spatial scales. We are testing if lakes act as accumulators of eDNA in the landscape by receiving transported eDNA from rivers. If lakes accumulate eDNA from their catchments, sampling them will provide the paradigm shift needed to vastly change the cost, speed and geographic scale with which species can be surveyed through time.

We sampled the Lac de Créteil, alongside scientists and citizen researchers from 55 countries, and even had time for lunch by the lake!

Teams: Horizontal Evolution of Algal Lifestyles (HEAL)

A starchy diet for Sapiens: when archaeology, palaeoanthropology and genetics meet

This video illustrates the research carried out as part of the STARCH4SAPIENS collaborative project funded by the French National Research Agency (ANR).

Illustration : Claudia Flandoli Animation : La Bande Destinée

Voice over : Sassy Clyde

Texts provided by : A. Carbone, L. Longo, S. Condemi

Teams: Analytical Genomics

Meet-EU

The first edition of Meet-EU was launched last Friday! Students enrolled in Bioinformatics Master programs from the 4EU+ alliance will join their efforts to predict chromatin organisation from Hi-C data. The LCQB is involved in the organisation of this edition, and in the training of the students!

The full opening session is available at: https://www.youtube.com/watch?v=-x5gzjqB6ms&feature=youtu.be.

Que peuvent nous dire les protéines

 

Que peuvent nous dire les protéines sur la manière dont elles interagissent et fonctionnent ensemble? Au LCQB, nous développons des approches computationnelles pour prédire les interactions protéiques, modéliser le comportement social des protéines et en déduire l’effet des mutations sur les réseaux d’interaction protéique.

 

Teams: Analytical Genomics

Cosa possono dirci le proteine

Cosa possono dirci le proteine su come interagiscono e lavorano insieme? Al LCQB sviluppiamo approcci computazionali per predire interazioni proteiche, per modellare il comportamento sociale delle proteine e per dedurre l’effetto delle mutazioni sulle reti di interazione proteica.

What can proteins tell us about how they interact and function together?

What can proteins tell us about how they interact and function together? 

At LCQB, we develop computational approaches to predict protein interactions, model protein social behaviour and infer the effect of mutations on protein interaction networks. We just posted this video explaining these ideas to the large public. 

Link to the french video

Link to the italian video

Teams: Analytical Genomics

Help Cure Muscular Dystrophy

A World Community Grid Lecture Series webcast describing the work done by the team and its collaborators on protein-protein interactions, within the framework of the “Help Cure Muscular Dystrophy” project can be found here.

Teams: Analytical Genomics