Local Interaction Signal Analysis (LISA) is an empirical function designed to estimate protein-protein binding affinities. It explores the geometry of contact distributions at protein-protein interfaces and enables to identify hot-sites of favorable contacts playing a major contribution in binding affinity. LISA applies to a large variety of complexes resulting in a very stable behavior. It outperforms all existing comparable predictor methods predicting binding affinity.

The Analytical Genomics team.
Link to the article.