Biology of Genomes
Quantitative Biology
Our research projects aim at understanding the biology of prokaryotic and eukaryotic genomes. We are combining experimental approaches based on molecular genetics and functional genomics to quantitative explorations of genome sequences requiring bio-informatic skills and the development of new tools. We are interested by the relationships between replication/recombination, the gene organization along chromosomes and their effect on gene expression in both yeast and bacteria. In yeast, we study the evolution of gene content and all mutational mechanisms leading to chromosomal rearrangements, variations of nucleotide composition and sequence polymorphisms at different scales, from cells to populations, and from strains to species. In bacteria, we are studying how chromosome structure can affect gene expression regulation as a function of the DNA replication cycle using single cell measurements.
Group Domain: Quantitative
